Anti-phospho eIF4B Antibody (Ser422) from rabbit, purified by affinity chromatography

Eukaryotic translation initiation factor 4B (eIF-4B), encoded by the gene name ELF4B, is an RNA-binding protein that is involved in translation of RNA molecules and consequent protein synthesis. ELF4B is required for the binding of mRNA to ribosomes. ELF4B also functions in close association with EIF4-F and EIF4-A. ELF4B has been demonstrated to bind near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. ELF4B promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. ELF4B contains multiple domains, including an N-terminal RNA recognition motif (RRM) and a C-terminal Arginine Rich Motif (ARM) that facilitate RNA binding. eIF4B may play a specific role in the assembly of the 48S initiation complex. Its translational activity is enhanced by phosphorylation of its ser406 and ser422 residues via the Ras-MAPK and PI3-K/mTOR pathways. eIF4B specially targets RNA molecules involved in cell proliferation and survival in response to signals converging from these pathways.