Anti-Catenin Delta-2 Antibody, clone 12B4 clone 12B4.1, from mouse

Catenin delta-2 (UniProt: Q9UQB3; also known as Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin) is encoded by the CTNND2 (also known as NPRAP) gene (Gene ID: 1501) in human. Delta Catenin is a component of the cadherin-catenin cell adhesion complex and is enriched in synaptosomes. Catenin Delta 2 is a member of the beta-catenin superfamily and is expressed in the brain where it is required for normal cognitive development and its highest expression is observed in fetal brain. Catenin Delta 2 is phosphorylated by Cdk5 and by GSK-3beta. Catenin Delta 2 plays a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. It is involved in the regulation of Wnt signaling where it acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3beta, phosphorylation, ubiquitination, and degradation. When bound to ZBTB33 (Zinc Finger and BTB Domain Containing 33), it functions as a transcriptional activator. The loss of CTNND2 gene has been associated with the intellectual disability observed in the cri du chat syndrome that is characterized by slow growth, microcephaly, delayed acquisition of psychomotor skills and intellectual disability. (Ref.: Yuan, L et al. (2015). J. Biol. Chem. 290(17):10947-57).