Anti-GAS2L1 from rabbit

GAS2-like protein 1 (UniProt: Q99501-1; also known as GAS2-related protein on chromosome 22, Growth arrest-specific protein 2-like 1, GAS2L1) is encoded by the GAS2L1 (also known as GAR22) gene (Gene ID: 10634) in human. GAS2L1 belongs to the growth-arrest-specific 2 (GAS2) family, whose members mediate the crosstalk between filamentous actin (F-actin) and microtubules. Three members of this family, known as GAS2L1, GAS2L2, and GAS2L3, are shown to be differentially involved in mediating the crosstalk between F-actin and microtubules. GAS2L1 is expressed in testis and brain, GAS2L2 is exclusively expressed in skeletal muscle, and GAS2L3 is found in many different cell types. Although they all localize to actin and microtubules, only the exogenous expression of GAD2L1 and GAS2L2 affect microtubule stability, dynamics, and guidance along actin stress fibers. GAS2L1 is reported to associate with the proximal end of mature centrioles and participates in centriole dynamics and centrosome disjunction. Loss of GAS2L1 can inhibit centrosome disjunction in the G2 phase. On the other hand, overexpression of GAS2L1 can induce premature centrosome separation, which also requires its association with actin, microtubules, and the microtubule end-binding proteins. (Ref.: Stroud MJ et al. (2014). J. Cell Sci. 127(12); 2672-2682; AU, FKC et al. (2017). Dev. Cell 40(1); 81-94).