Back to Previous Page

Anti-INK4b (p15) Antibody, clone GF10 (10C7A6) culture supernatant, clone GF10 (10C7A6), from mouse

ITEM#: 3042-MABE1664

MFR#: MABE1664

Cyclin-dependent kinase 4 inhibitor B (UniProt P42772; also known as MTS-2, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b, p15INK4B) is encoded by the CDKN2B (also known as MTS2) gene (Gene ID 1030) in human. The INK and CIP/KIP families of cycli

Cyclin-dependent kinase 4 inhibitor B (UniProt P42772; also known as MTS-2, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b, p15INK4B) is encoded by the CDKN2B (also known as MTS2) gene (Gene ID 1030) in human. The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation. INK4a and INK4b (encoded by the CDKN2A and CDKN2B gene, respectively) constitute the INK4 subfamily of CDKis. INK4a and INK4b are induced by oncogenic Ras and are involved in cell cycle G1 arrest and cellular senescence. Inactivation of CDKN2A and CDKN2B are found in a wide variety of human malignancies and murine tumor models.