Anti-LAMC2 Antibody

Laminin subunit g2 (UniProt: Q13753; also known as Cell-scattering factor 140 kDa subunit, CSF 140 kDa subunit, Epiligrin subunit gamma, Kalinin subunit gamma, Kalinin/nicein/epiligrin 100 kDa subunit, Ladsin 140 kDa subunit, Laminin B2t chain, Laminin-5 subunit gamma, Large adhesive scatter factor 140 kDa subunit, Nicein subunit gamma) is encoded by the LAMC2 (also known as LAMB2T, LAMNB2) gene (Gene ID: 3918) in human. Laminin is a major basement membrane glycoprotein consisting of alpha, beta, gamma chains that are bound to each other by disulfide bonds. Over 15 different isoforms have been reported in the laminin family that are expressed in a tissue-specific manner and play different role in each tissue. gamma2, a subunit of Laminin-5 is reported to be frequently over-expressed as a monomer or as the beta2-gamma3 heterodimer in invasive cancers and is regarded as an invasion marker. It has 8 EGF-like domains. The cell adhesion and motility activities of Laminin-5 are reported to be regulated by the proteolytic cleavage of the short arm of Laminin gamma2 chain by BMP-1 or MT1-MMP. This cleavage releases a 45 kDa N-terminal proteolytic fragment (gamma2pf). The short arm and gamma2pf can be further cleaved by serine proteases and by matrix metalloproteinases resulting in the release of small N-terminal fragments. gamma2pf-like fragments have been reported to be present in conditioned media of cultured cancer cells and in sera from human cancer subjects. Clone P2H targets the second N-terminal EGF-like repeat (NE2) of domain V of laminin 2. (Ref.: Sato, H., et al. (2014). Cancer Sci. 105(2); 168-175; Miyazaki, K., et al. (2016). Cancer Sci. 107(12); 1909-1918).