Anti-LOX-1 Antibody, clone 15C4 clone 15C4, from mouse

Oxidized low-density lipoprotein receptor 1 (UniProt: P78380; also known as Ox-LDL receptor 1, C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1) is encoded by the OLR1 (also known as CLEC8A, LOX1) gene (Gene ID: 4973) in human. LOX1 is a type II transmembrane receptor for oxidatively modified low density lipoprotein (oxLDL), a well-known marker of atherosclerosis. A free form of LOX-1 has also been reported. LOX-1 has a The C-type lectin domain that mediates the recognition and binding of oxLDL. Its cytoplasmic region is considered to be essential for subcellular sorting on the cell surface. LOX-1 is expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. It is also expressed at the surface of dendritic cells. LOX-1 mediates the recognition, internalization and degradation of oxLDL by vascular endothelial cells. OxLDL induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and also apoptosis. In addition to binding oxLDL, LOX-1 also acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. LOX-1 is up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress.