Anti-Nur77 Antibody from rabbit, purified by affinity chromatography

Nurr77 is an internal nuclear receptor that is expressed developmentally and in the adult in many tissues including the liver, brain and thyroid. In the liver it acts along with other transcription factors to govern liver development as well as regeneration in the adult. Nur77 also participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Nur77 is also a potent pro-apoptotic protein, particularly in the brain and heart where translocation of Nur77 into the mitochondria where it induces apoptosis. Interestingly in certain cancers Nur77 overexpression is associated with pro-oncogenic activity and regulating energy levels which promotes proliferation and survival in cancer cells.