Anti-Pancreatic Lipase/PNLIP Antibody serum, from rabbit

Pancreatic triacylglycerol lipase (EC 3.1.1.3; UniProt P35638; also known as Pancreatic lipase, PL, PTL, Triacylglycerol acylhydrolase) is encoded by the PNLIP (Also known as PNLIPD) gene in human (Gene ID 5406). PTL is a pancreas synthesized carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides (TAGs). The dietary TAGs are partially digested by the gastric lipase in the stomach. The emulsion particles then mix with digestive enzymes from the pancreas in the duodenum where digestion proceeds. The pancreas secretes multiple lipases, including pancreatic triglyceride lipase (PTL), carboxyl ester lipase (CEL), and pancreatic lipase-related protein-1 and -2 (PLRP1 & PLRP2). Unlike PLRP2, PLRP1 exhibits little activity against triglycerides and no measurable activity against phospholipids, galactolipids or cholesterol esters. Experimental evidences suggest that PLRP1 plays a negative regulatory role against PLT-colipase-mediated dietary triglyceride digestion. Pancreas-derived lipases are essential for the efficient digestion of dietary TAG. Pancreatic insufficiency or exocrine pancreas failure results in steatorrhea or steatorrhoea, where increased fat excretion is seen in fecal samples.