Anti-phospho BRD4 (Ser492) from rabbit

Bromodomain-containing protein 4 (UniProt O60885; also known as MCAP, Mitotic chromosome-associated protein, Protein HUNK1) is encoded by the BRD4 (also known as HUNK1, MCAP) gene (Gene ID 23476) in human. BRD4 is a BET (bromodomain and extra-terminal) protein family member that functions as a chromatin reader by binding acetylated lysines in histones. BRD4 is an important transcription regulator in many cell types, including transcription in response to external cues. BRD4 plays an essential role in neuronal function and mediates the transcriptional regulation underlying learning and memory. BRD4 regulates IEG transcription in neurons upon phosphorylation by casein kinase 2 (CK2), which is activated in response to neuronal stimulation. Brd4 knockout in mice is lethal, while Brd4 function blockage by inhibitor JQ1 (Cat. No. 500586) treatment is reported to affect the transcription of critical synaptic proteins, resulting in memory deficits and decreased seizure susceptibility in mice.