Anti-RTN3 (R458) from rabbit

Reticulon-3 (UniProt O95197; also known as HAP, Homolog of ASY protein, Neuroendocrine-specific protein-like 2, Neuroendocrine-specific protein-like II, NSP-like protein 2, NSP-like protein II, NSPLII) is encoded by the RTN3 (also known as ASYIP, NSPL2) gene (Gene ID 10313) in human. Reticulon-3/RTN3 belongs to the RTN family of proteins characterized by their C-terminal reticulon homolog domain (RHD; a.a. 844-1032 in RTN3). There exist four mammalian reticulons (RTN1-4), with each member having multiple spliced isoforms. RTN3 is expressed in neurons and localized in axons and growth cones. RTN3 overexpression in neurons results in reduced amyloid deposition in murine models of Alzheimer's disease (AD). Consistently, RTN3 deficiency elevates BACE1 protein level and enhances amyloid deposition in AD mice that express human mutant APP and presenilin-1 transgenes. Human RTN3 is a multipass ER and golgi membrane protein with 3 membrane helical regions (a.a. 864-997, 948-968, 973-993) and four cytoplasmic regions (a.a. 2-863, 888-947, 969-972, 994-1032). Its C-terminal RHD mediates interaction with FADD (a.a. 987-1032) and BACE1 (a.a.1000-1002). Alternative splicings generate 7 isoforms (UniProt O95197-1 througth O95197-7).