Anti-SETD5 from rabbit, purified by affinity chromatography

SET domain-containing protein 5 (UniProt: Q9C0A6; also known as Setd5) is encoded by the SETD5 (also known as KIAA1757) gene (Gene ID: 55209) in human. Setd5 protein is shown to be essential for mammalian development and is required for regulating germ cell-associated genes in embryonic stem cells. It interacts with Tbl1xr1 and Ctr9, which are components of 2 different transcriptional regulatory complexes (NcoR1 corepressor complex and Paf1 complex) in murine embryonic stem cells. Setd5-deficient embryonic stem cells display impaired cellular proliferation, increased apoptosis, defective cell cycle progression, a diminished ability to differentiate into cardiomyocytes, and greatly perturbed gene expression. Setd5-deficient mouse embryos exhibit severe defects in neural tube formation, somitogenesis and cardiac development, have aberrant vasculogenesis in embryos, yolk sacs, and placentas. They die between embryonic day 10.5 and 11.5. Three isoforms of Setd5 have been reported that are produced by alternative splicing. Its SET domain is localized to amino acids 269-390. Mutation in SETD5 gene has been linked to intellectual disability. (Ref.: Yu, SE., et al. (2017). Cell. Biochem. Funct. 35(5); 247-253; Osipovich, AB., et al. (2016). Development 143(24); 4595-4607).