Anti-Syndecan-1 Antibody, clone 11G2.1 clone 11G2.1, from mouse

Syndecan-1 (UniProt P18827; also known as CD138, SYND1) is encoded by the SDC1 (also known as SDC) gene (Gene ID 6382) in human. Syndecan-1 belongs to a family of transmembrane heparan sulfate proteoglycans (HSPGs), members of which also include syndecan-2 (fibroglycan, SDC2), syndecan-3 (N-syndecan, SDC3), and syndecan-4 (amphiglycan, ryudocan, SDC4). Syndecan-1 is produced with a signal peptide (a.a. 1-22), the removal of which yields the mature protein with a large extracellular region (a.a. 23-254), a transmembrane segment (a.a. 255-275), and a cytoplasmic tail (a.a. 276-310). Syndecan-1 is modified at its extracellular domain on a.a. 45 and 47 with O-linked heparan sulfate (HS) that plays an important role in mediating its interaction with HS-binding protein, including growth factors (e.g. bFGF/FGF2, PDGF, TGF-beta, and VEGF) and extracellular matrix proteins (e.g. collagens, fibronectin, thrombospondin, and tenascin). Syndecan-1 thus funtions as a coreceptor for growth factor receptors and acts as an anchor connecting the extracellular matrix to the intracellular cytoskeleton. Syndecan extracellular domain can be proteolytically cleaved off at a juxtamembrane site and upregulated shedding of the ectodomain occurs in response to growth factors, chemokines, heparanase, microbial toxins, insulin, and cellular stress. SDC1 deregulation contributes to cancer progression by promoting angiogenesis and cancer cell proliferation, metastasis, and invasion.