Anti-TRAP-1 Antibody, clone TR-1 clone TR-1, from mouse

Heat shock protein 75 kDa, mitochondrial (UniProt Q12931; also known as HSP 75, TNFR-associated protein 1, TRAP-1, Tumor necrosis factor type 1 receptor-associated protein) is encoded by the TRAP1 (also known as HSP75) gene (Gene ID 10131) in human. The mammalian HSP70 family consists of the mitochondrial HSP75 (TRAP-1), the endoplasmic HSP78, the cytoplasmic HSC70 (a.k.a. HSC73 and HSP73) and its inducible counterpart HSP72 (a.k.a. HSP70). TRAP-1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis. TRAP1-deficiency results in enhanced mitochondrial respiration and fatty acid oxidation, as well as increased cellular accumulation of tricarboxylic acid cycle intermediates, ATP, and reactive oxygen species species. TRAP-1-deficient cells display suppressed glucose metabolism and strikingly enhanced invasiveness, implicating a tumor suppressor role of TRAP-1.