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BrdT (257-382) human recombinant, expressed in E. coli, >=98% (SDS-PAGE)

ITEM#: 3042-SRP6563100UG

MFR#: SRP6563-100UG

BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. It also controls the

BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids. It may play a role in the transcriptional regulation of spermatogenesis. It also seems to have a structural ATP-independent role in the reorganization of acetylated chromatin. Therecombinant protein includes Bromo 1 domain (257-382 aa) with N-terminal His-tag.