The gene GCN1L1 (general control of amino-acid synthesis 1-like protein 1) is mapped to human chromosome 12q24. In Saccharomyces cerevisiae, the protein was shown to localize in the cytoplasm. Like in Saccharomyces, human GCN1L1 contains an EF3 (tran
alpha-D-Galactosidase A (GLA), a lysosomal enzyme, is a glycoside hydrolase that removes alpha-galactosyl moieties from glycolipid and glycoprotein glycans. Lack of GLA results in the accumulation of globotriaosylsphingosine (Gb3) in a variety of tis
G-patch (glycine-rich) domain and KOW (Kyrpides, Ouzounis and Woese) domain (GPKOW) is a RNA-binding protein that binds to RNA via pathway modulated by PKA (protein kinase A). It is present in human spliceosome. GPKOW is also known as T54 protein or
The gene protein Hook homolog-1 (HOOK1) is mapped to human chromosome 1p32.1. It belongs to HOOK family of proteins. HOOK1 transcript is highly expressed in testis. The protein localizes to discrete punctate subcellular structures.