AlphaLISA High Performance Human IL-10 Detection Kit, 500 Assay Points

The AlphaLISA High Performance (HP) Human IL-10 Detection Kit is designed for the quantitative determination of human IL-10 in serum, buffered solution, or cell culture medium using a homogeneous (no wash steps, no separation steps) assay. This kit is the new and improved version of part number AL218. Human Interleukin 10 (IL-10) is a homodimer composed of two subunits of 18 kDa each. It is produced by various T-cell populations, monocytes, macrophages, and different cell types in the liver when stimulated by endogenous or exogenous factors such as stress, exotoxins, TNF-?;, and catecholamines. IL-10 inhibits interferon synthesis in Th1 cell clones, monocytes, and macrophages. IL-10 also inhibits antigen presentation to T-cells and IL-12 production by monocytes. It also impairs the proliferation and cytokine synthesis of CD4+ T cells, without having a direct inhibitory effect on CD8+ T cells. On the other hand, IL-10 has a stimulatory effect on B cells, prevents apoptosis and enha