AlphaLISA High Performance Human IL-17A Detection Kit, 100 Assay Points

The AlphaLISA High Performance (HP) Human IL-17A Detection Kit is designed for the quantitative determination of human IL-17A in serum, buffered solution, or cell culture medium using a homogeneous (no wash steps, no separation steps) assay. This kit is the new and improved version of part number AL219. Human Interleukin 17 (IL-17 or IL-17A) is a homodimer formed by two ~15 kDa subunits produced by a subset of T helper cells named Th17. It is a proinflammatory cytokine that enhances T-cell priming and stimulates macrophages, fibroblasts, endothelial, and epithelial cells to produce multiple mediators of inflammation such as IL-1, IL-6, TNF-?;, NOS-2, metalloproteases, and chemokines. IL-17 has been implicated in the proinflammatory patterns associated with joint inflammation and rheumatoid arthritis (RA) in mouse and human models. It is also critical for neutrophil activation and migration, and induces IL-8, a key chemokine for neutrophils. IL-17 signals through IL-17R, which in m