AlphaLISA SureFire Ultra Human and Mouse Phospho-TAK1 (Thr184/187) Detection K

The AlphaLISA SureFire Ultra Human and Mouse Phospho-TAK1 (Thr184/187) assay is a sandwich immunoassay for quantitative detection of phospho-TAK1 (Thr184/187) in cellular lysates using Alpha Technology. . Transforming growth factor ?-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and a key regulator of the innate immunity and the proinflammatory signaling pathways. TAK1 facilitates the activation of the nuclear factor B (NF-?B), c-Jun N-terminal kinase (JNK), and p38 pathways in response to the inflammatory proteins interleukin-1 (IL-1), tumor necrosis factor (TNF), and toll-like receptor (TLR) agonists. In addition, TAK1 mediates the signaling from T- and B-cell receptors, which is a crucial component of adaptive immunity. TAK1 is associated with various autoimmune diseases (rheumatoid arthritis, inflammatory bowel syndrome, kidney disease, skin inflammation, chronic pain) and cancers (mantle cell lymphoma, breast cancer, colon cancer). The A