AlphaLISA SureFire Ultra Human and Mouse Total ATF-4 Detection Kit, 500 Assay

The AlphaLISA SureFire Ultra Human and Mouse Total ATF-4 assay is a sandwich immunoassay for quantitative detection of total ATF-4 in cellular lysates using Alpha Technology. . Activating transcription factor 4 (ATF-4), also known as tax-responsive enhancer element B67, is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF-4 is a member of a family of DNA-binding proteins that includes AP-1 family, CREBs, and CREB-like proteins, all of which share a leucine zipper region that is involved in protein-protein interactions. Under stress conditions, PERK pathway rapidly stimulates the expression of NRF2 through activating transcription factor 4 (ATF4) that contributes to the NRF2 protective response. The AlphaLISA SureFire Human and Mouse Total ATF-4 Detection Kit is a sandwich immunoassay for the quantitative detection of total ATF-4 in cellular lysates, using Alpha Technology. Formats The HV (high volume) kit contains reagents to