AlphaLISA SureFire Ultra Human and Mouse Total CREBBP Detection Kit, 10,000 As

The AlphaLISA SureFire Ultra Human and Mouse Total CREBBP assay is a sandwich immunoassay for quantitative detection of total CREBBP in cellular lysates using Alpha Technology. . The transcription coactivator CREB binding protein (CREBBP or CBP) is an acetyl transferase, that mediates histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters. CREBBP/CBP inhibitors and degraders reduce H3K27ac, down-regulate oncogene transcription, induce cancer cell growth inhibition and cell death, activate immune response, overcome drug resistance and suppress tumor progression in vivo. CREBBP/CBP is over-expressed in cancer cells and in drug-resistant cancer cells, it activates oncogene transcription and induces cancer cell proliferation, survival, tumorigenesis, metastasis, immune evasion and drug-resistance. The AlphaLISA SureFire Human and Mouse Total CREBBP Detection Kit is a sandwich immunoassay for the quantitative detection of total CREBBP in