AlphaLISA SureFire Ultra Human Total Parkin Detection Kit, 500 Assay Points

The AlphaLISA SureFire Ultra Human Total Parkin assay is a sandwich immunoassay for quantitative detection of total Parkin in cellular lysates using Alpha Technology. . Parkin, encoded by the PARK2 gene, is an E3 ubiquitin ligase which has a neuroprotective role in combination with the Ser/Thr kinase PINK1 by acting in a mitochondrial quality control pathway. Since mitochondria are continuously exposed to intra and extra mitochondrial threats including reactive oxygen species (ROS), the removal of damaged mitochondria is critical for maintaining cellular homeostasis. Dysfunction of Parkin represents both a predominant cause of familial parkinsonism but also a formal risk factor for the more common, sporadic form of Parkinson's disease (PD). The AlphaLISA SureFire Human Total Parkin Detection Kit is a sandwich immunoassay for the quantitative detection of total Parkin in cellular lysates, using Alpha Technology. Formats: The HV (high volume) kit contains reagents to run 10