HTRF Phospho-RAB10 (Thr73) Detection Kit, 50,000 Assay Points

This HTRF kit enables the cell-based quantitative detection of RAB10 phosphorylation at Thr73, which is a key regulator of intracellular vesicular transport. RAS-related protein Rab10 (RAB10) belongs to the RAS superfamily of small GTPases. RAB10 is a key regulator of intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane-bound organelles and vesicles. LRRK2-mediated phosphorylation may cause deficits in endolysosomal trafficking pathways modulated by RAB10, contributing to the onset of neurodegenerative disease. RAB10 is associated with Alzheimer 's Disease and Parkinson 's Disease.