Anti-26S proteasome regulatory subunit RPN11, clone 7C7.1 Antibody clone 7C7.1, from mouse

26S proteasome non-ATPase regulatory subunit 14 is also known as 26S proteasome regulatory subunit RPN11 or 26S proteasome-associated PAD1 homolog 1. This protein is expressed from the PSMD14 gene and is the metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. 26S proteasome non-ATPase regulatory subunit 14 has a role in the response to double-strand breaks (DSBs) by regulating non-homologous end joining (NHEJ) via cleaving 'Lys-63'-linked polyubiquitin, retaining JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. 26S proteasome non-ATPase regulatory subunit 14 is also involved in homologous recombination repair by promoting RAD51 loading. 26S proteasome non-ATPase regulatory subunit 14 is widely expressed, but found in the highest levels in heart and skeletal muscle.