Anti-ABCA1 Antibody, clone MABI98-7 clone MAB198-7, from rat

ATP-binding cassette sub-family A member 1, also known as ATP-binding cassette transporter 1 (ABC-1), or ATP-binding cassette 1, and encoded by the gene name Abca1 or Abc1, is a cAMP-dependent and sulfonylurea-sensitive anion transporter. ABCA1 is a member of the ABC transporter superfamily and the ABCA family. ABCA1 is a key gatekeeper influencing intracellular cholesterol transport. ABCA1 has two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain, and may act as a multifunctional polypeptide. ABCA1 has been shown to be down-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). ABCA1 interacts with MEGF10 and is widely expressed in adult tissues, with the highest levels found in uterus and pregnant uterus. Mutations in the ABCA1 gene are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking.