Anti-C-Reactive Protein Antibody, clone 2A8.1 clone 2A8.1, from mouse

C-reactive protein (UniProt P02741) is encoded by the CRP (also known as PTX1) gene (Gene ID 1401) in human. CRP is the classical acute phase reactant produced by the liver and its circulating concentration increases rapidly in a cytokine-mediated response to tissue injury, infection, and inflammation. It is an annular, pentameric protein that binds to lysophosphatidylcholine expressed on the surface of dead or dying cells and bacteria in order to activate the complement system via the C1Q complex. Interleukin-6 (IL-6), produced by macrophages in response to injury and infection, is a major trigger for the synthesis of CRP by the liver. It plays a major role in early host defense by promoting agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine. It can also interact with DNA and histones and scavenge nuclear material released from damaged circulating cells.