Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elemen
Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation on by various kinases, including PKA and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.
Ezrin (UniProt Q8HZQ5; also known as Cytovillin, Villin-2, p81) is encoded by the EZR (also known as VIL2) gene (Gene ID 100008846) in Oryctolagus cuniculus (Rabbit) species. Ezrin, radixin, and moesin are the three ERM protein family members that cr
Synaptophysin (UniProt P08247; also known as Major synaptic vesicle protein p38) is encoded by the SYP (also known as MRX96, MRXSYP) gene (Gene ID 6855) in human. Synaptophysin is a 38 kDa four-transmembrane glycoprotein on synaptic vesicle (SV) with
Nucleophosmin (UniProt P06748; also known as B23, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin) is encoded by the NPM1 (also known as NPM) gene (Gene ID 4869) in human. Nucleophosmin (NPM) is a nucleolar protein that plays a ro
8-Oxoguanine is a mutagenic oxidative damage product of guanine. Oxidatively damaged base 8-oxoguanine is generated in the DNA of all living organisms due to the presence of reactive oxygen species in cells. DNA damage threatens the health of the gen
Laminin subunit gamma-1 (UniProt P11047; also known as Laminin B2 chain, Laminin-1/-2/-3/-4/-6/-7/-8/-9/-10/-11 subunit gamma, S-laminin subunit gamma, S-LAM gamma) is encoded by the LAMC1 (also known as LAMB2) gene (Gene ID 3915) in human. Laminins
Voltage-dependent L-type calcium channel subunit alpha-1S (UniProt P07293; also known as Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, Voltage-gated calcium channel subunit alpha Cav1.1) is encoded by the CACNA1S (also kno
Laminin subunit alpha-5 (UniProt: O15230; also known as Laminin-10 subunit alpha, Laminin-11 subunit alpha, Laminin-15 subunit alpha) is encoded by the LAMA5 (also known as KIAA0533, KIAA1907) gene (Gene ID: 3911) in human. Laminins are a family of h
Synaptosomal-associated protein 25 (UniProt P60880; also known as SNAP-25, SUP, Super protein, Synaptosomal-associated 25 kDa protein) is encoded by the SNAP25 (also known as SNAP) gene (Gene ID 6616) in human. SNAP-25 belongs to the superfamily of s
POU domain, class 2, transcription factor 1 (UniProt P14859; also known as NF-A1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, OTF-1) is encoded by the POU2F1 (also known as OCT1, OTF1) gene (Gene ID 5451) in human. Oct-1