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Anti-MDM2 Antibody, clone IF2, Alexa Fluor(R) 555 Conjugate clone IF2, from mouse, ALEXA FLUOR(R) 555

ITEM#: 3042-MABE340AF555

MFR#: MABE340-AF555

E3 ubiquitin-protein ligase Mdm2 (UniProt Q00987; also known as Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2) is encoded by the MDM2 gene (Gene ID 4193) in human. MDM2 is an E3 ubiquitin ligase that is most widely studied

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E3 ubiquitin-protein ligase Mdm2 (UniProt Q00987; also known as Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2) is encoded by the MDM2 gene (Gene ID 4193) in human. MDM2 is an E3 ubiquitin ligase that is most widely studied for its role in regulating the p53 tumor suppressor. MDM2 antagonizes p53 transcriptional activity by binding to and blocking p53 N-terminal trans-activation domain. MDM2 can also monoubiquitinate p53, thereby promoting p53 cytoplasmic localization to prevent p53 nuclear funtion. In addition, MDM2, when in complex with p300, also mediates p53 polyubiquitination, resulting in p53 proteosomal degradation. MDM2 overexpression is shown to inhibit DNA double-strand break repair mediated through its interaction with Nbs1 in a p53-independent manner.
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Product Name Description Item# QTY
Anti-MDM2 Antibody, clone IF2, Alexa Fluor(R) 488 Conjugate clone IF2, from mouse, ALEXA FLUOR(R) 488 E3 ubiquitin-protein ligase Mdm2 (UniProt Q00987; also known as Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2) is encoded by the MDM2 gene (Gene ID 4193) in human. MDM2 is an E3 ubiquitin ligase that is most widely studied 3042-MABE340AF488 EA
Anti-Tau Antibody, clone PC1C6, Alexa Fluor(R) 555 Conjugate clone PC1C6, from mouse, ALEXA FLUOR(R) 555 Microtubule-associated protein tau (UniProt P29172; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU) gene (Gene ID 281296) in bovine species. Extracellular plaque deposits 3042-MAB3420AF555 EA
Anti-Ras Antibody, clone RAS10, Alexa Fluor 555 Conjugate Ras proteins are small GTPases controlling cellular pathways that signal for growth, proliferation, and differentiation. Mammalian genomes harbor three Ras genes (HRAS, NRAS, and KRAS) that encode four GTPases, two of which (K-Ras4A and K-Ras4B) are 3042-05516AF555 EA
Anti-Sox9 Antibody, Alexa Fluor(R) 555 conjugate from rabbit, ALEXA FLUOR(R) 555 Transcription factor SOX-9 (UniProt P48436; also known as Sex-determining region Y-box 9 protein, SRY-related HMG-box gene 9) is encoded by the SOX9 (also known as CMD1, CMPD1, SRA1) gene (Gene ID 6662) in human. Sox family of genes are related to th 3042-AB5535AF555 EA
Anti-Actin Antibody, clone C4, Alexa Fluor(R) 555 Conjugate clone C4, from mouse, ALEXA FLUOR(R) 647 Actins are ubiquitous eukaryotic proteins that serve as a multi-functional, basic building blocks of cytoskeletal microfilaments. They play critical roles in a wide range of cellular processes, including cell division, cell migration, chromatin remod 3042-MAB1501AF555 EA
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