Anti-Myosin-2 (MYH2) Antibody, clone SC-71 clone SC-71, from mouse

Myosin-2 (UniProt Q9BE41; also known as MyHC-2a, MyHC-IIa, Myosin heavy chain 2, Myosin heavy chain 2a, Myosin heavy chain IIa, Myosin heavy chain, skeletal muscle, adult 2) is encoded by the MYHSA gene (Gene ID 788772) in bovine species. Myosin heavy chain (MyHC) is a major structural component of the striated muscle contractile apparatus and is essential for body movement and cardiac contractility. MyHC are encoded by a highly conserved multigene family, of which eight isoforms have been identified in mammals, each encoded by a separate gene that displays distinct temporal-spatial regulation. MyHC-2a is expressed in the fast-type 2A muscle fibers. Recessive MyHC-2a myopathy caused by missense mutations results in mild muscle weakness. Autosomal dominant mutation (E706K) is reported to cause defective muscle function and compromises the structural integrity of all muscle cells. Ref.: Tajsharghi, H et al. (2014). Eur. J. Hum. Genet. 22: 801-808.