Anti-Myosin-3 (MYH3) Antibody, clone BF-G6 clone BF-G6, from mouse

Myosin-3 (UniProt A6QPA6; also known as Muscle embryonic myosin heavy chain, Myosin heavy chain 3, MYH3, Protein, Myosin heavy chain, fast skeletal muscle, embryonic, SMHCE) is encoded by the MYH3 gene (Gene ID 281338) in bovine species. Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. MYH3 is predominantly expressed during fetal development and its expression declines rapidly after birth. It is not normally present in adult muscle except during muscle regeneration. Mutations in MYH3 are known cause two congenital contracture syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome, the most severe forms of distal arthrogryposis (DA). Ref.: Pokrzywa, M., et al. (2015). PLoS One. 10(11):e0142094; Toydamir, R.M., et al. (2006). Nature Genet. 38(5):561-565.