NeuroD1 is a transcriptional activator that associates with p300 transcription co-activator protein to promote the expression of many important differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear
NeuroD1 is a transcriptional activator that associates with p300 transcription co-activator protein to promote the expression of many important differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. NeuroD1 is required for amacrine cell fate as well as dendrite morphogenesis and the maintenance of cerebellar cortex. Also via its associate with chromatin, NeuroD1 helps regulate the expression of many other key transcriptional regulators of neurogenesis as well. NeuroD1 is expressed in developing brain and pancreas as well as in differentiating neurons in both the CNS and PNS systems. Disruption of NeuroD1 leads to early death in mice with several developmental and functional defects throughout the body pointing to this factors key role in development in many systems.
RAB27B, also known as C25KG, is a member of the Rab GTPase superfamily. RAB27B acts as a lipid anchoring protein that is prenylated and works in vesicular fusion and protein trafficking within cells. The protein is most highly expressed in testis but
Angiomotin is a cell surface protein that plays a central role in tight junction maintenance and the uptake of proteins at tight junctions but also appears to regulate endothelial cell response and their migration toward growth factors as well as the
Divalent metal ion transporter 1 (DMT1) is a proton-coupled Fe2+ transporter that is essential for iron uptake in enterocytes and for transferrin-associated endosomal iron transport in many other cell types. DMT1 dysfunction is associated with severa
Forkhead box protein K2 (UniProt Q01167; also known as FOXK2, Cellular transcription factor ILF-1, Interleukin enhancer-binding factor 1) is encoded by the FOXK2 (also known as ILF, ILF-1, ILF1) gene (Gene ID 3607) in human. FOXK2 is a transcription
Methylenetetrahydrofolate reductase or 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20; UniProt P42898) is encoded by the MTHFR gene (Gene ID 4524) in human. MTHFR catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrof
Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.8; UniProt Q99518; also known as Dimethylaniline oxidase 2, FMO 1B1, FMO 2, Pulmonary flavin-containing monooxygenase 2) is encoded by the FMO2 (also known as FMO1B1) gene (Gene ID 2327) i
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (UniProt Q9NZC9; also known as ATP-driven annealing helicase, HepA-related protein, hHARP, SMARCA-like protein 1, Sucrose nonfermenting protein 2-like
Protein Jumonji (Jarid2), also known as Jumonji/ARID domain-containing protein 2, and encoded by the gene name Jarid2 is a member of the JARID2 family. Jarid 2 is a regulator of histone methyltransferase complexes, and therefore plays an essential ro
The Gbeta5 (GNB5 guanine nucleotide binding protein (G protein), beta 5) is a G protein subunit present predominantly in the central nervous system. This protein appears to be expressed in two forms, one found in the brain of 39 kDa and one found in