Anti-Periostin Antibody, clone 5B2.3 clone 5B2.3, from mouse

Periostin (UniProt Q15063; also known as OSF-2, Osteoblast-specific factor 2, PN) is encoded by the POSTN (also known as PSF2) gene (Gene ID 10631) in human. Periostin is an extracellular matrix (ECM) protein predominantly expressed in collagen-rich fibrous connective tissues, including heart valves, tendons, perichondrium, periosteum, and periodontal ligament (PDL). Periostin plays an essential role in the process of remodeling during tissue/organ development/repair and inflammation. Periostin derived from fibroblasts is shown to induce keratinocytes differentiation and proliferation. Periostin is a mediator for epidermal hyperplasia and is highly expressed in the dermis of both atopic dermatitis (AD) and psoriasis patients. Periostin level is also reported to be upregulated in patients with acute or chronic hepatitis and correlates well with serum TGF- 1 and TGF- 2 levels. The PDL-POSTN spliced isoform is predominantly expressed in PDL, it binds integrin v 3 with a higher affinity and induces strong activation of the integrin v 3-focal adhesion kinase (FAK) signaling pathway. Periostin is produced with a signal peptide (a.a. 1-21), the removal of which yields the mature protein with an N-terminal cysteine-rich EMI (a.a. 40-94) domain and four asciclin I or FAS1 domains (a.a. 97-230, 234-365, 368-492, 496-628). Alternative splicing generate several C-terminal domain variants with tissue-specific expression patterns.