Anti-Septin-9 Antibody, clone 10C10 clone 10C10, from mouse

Septin-9 (UniProt Q9UHD8; also known as MLL septin-like fusion protein, MLL septin-like fusion protein MSF-A, Ovarian/Breast septin, Ov/Br septin, SeptD1, Septin D1) is encoded by the SEPT9 (also known as AF17q25, KIAA0991, MSF, MSF1, PNUTL4, SINT1) gene (Gene ID 10801) in human. Septins are GTPases capable of forming higher-order oligomers and filamentous polymers that contact with cell membrane and cytoskeleton. Septins are involved in various cellular processes, including cytokinesis, karyokinesis, exocytosis, and cell shape maintenance. Septins exist in complexes that are composed of ordered non-polar arrays of multiple different septins. Human genome contains 13 septin genes that are grouped into the SEPT2 subgroup (septins 1, 2, 4, and 5), the SEPT6 subgroup (septins 6, 8, 10, 11, and 14), the SEPT3 subgroup (septins 3, 9, and 12), and the SEPT7 subgroup (septin 7). Among mammalian septins, septin-9 undergoes the most alternative splicings, alteration in septin-9 isoforms expression has been linked to cancer and SEPT9 gene mutations have been linked to hereditary neuralgic amyotrophy. Cdk1-catalyzed septin-9 Thr24 phosphorylation is reported to promote septin-9 interaction with the peptidylprolyl isomerase Pin1. Genetic knockdown of either protein results in abscission defect during cell division.