AlphaLISA SureFire Ultra Human and Mouse Phospho-PDHA1 (Ser293) Detection Kit,

The AlphaLISA SureFire Ultra Human and Mouse Phospho-PDHA1 (Ser293) assay is a sandwich immunoassay for quantitative detection of phospho-PDHA1 (Ser293) in cellular lysates using Alpha Technology. . Pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) is an enzyme involved in the pyruvate dehydrogenase complex (PDC). PDC is a multi-enzyme complex of the mitochondria that provides a link between glycolysis and the Krebs cycle and plays an essential role in producing acetyl-CoA from glucose leading to ATP or energy production. The PDHA1 enzyme is regulated by phosphorylation and dephosphorylation. Diseases associated with PDHA1 include pyruvate dehydrogenase E1-alpha deficiency, X-linked Leigh syndrome, and numerous solid tumor cancers. The AlphaLISA SureFire Ultra Human and Mouse Phospho-PDHA1 (Ser293) is a sandwich immunoassay for the quantitative detection of phospho-PDHA1 (Ser293) in cellular lysates, using Alpha Technology. Formats: The HV (high volume) kit contains reage