AlphaLISA Surefire Ultra Human Total FOXM1 Detection Kit, 500 Assay Points

The AlphaLISA SureFire Ultra Human Total FOXM1 assay is a sandwich immunoassay for quantitative detection of total FOXM1 in cellular lysates using Alpha Technology. Forkhead box protein M1 (FOXM1) is a transcription factor expressed throughout the cell cycle, rising in late G1-phase, reaching its apex in S-phase, and remaining there in G2/M and late M-phase. FOXM1 plays a significant role in multiple key cell cycle phases and is known as the master regulator of the cell cycle. The transcriptional network associated with FOXM1 regulates many processes, including stemness, cell survival, DNA damage repair, DNA replication, cell G1/S transition, cell cycle, cell proliferation, clonal formation, migration capacity, invasion, metastasis, and tumor initiation and progression. FOXM1 is found to be overexpressed in numerous malignancies such as breast, colorectal, hepatocellular, ovarian, lung, and pancreatic cancers. The AlphaLISA SureFire Human Total FOXM1 Detection Kit is a san