The Total CREB kit monitors cellular CREB expression level and can be used as a normalization assay for the phospho-CREB kits..The Total CREB cellular assay monitors total CREB and is used as a normalization assay with our phospho-CREB kits. This kit is compatible with the buffers from the phospho-CREB kit, so the same lysate can be used for analyses of both the phosphorylated and the total protein populations. CREB functions as a transcription factor, signaling downstream from MAPK/ERK and activated by several pathways, such as MAPK/ERK, PI3K/AKT, and stress signaling. CREB plays a critical role in promoting neuronal plasticity, cognitive abilities, cell proliferation, survival, and glucose homeostasis..