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Anti-DNA polymerase II subunit A Antibody, clone 9F11.1 clone 9F11.1, from mouse

ITEM#: 3042-MABE966

MFR#: MABE966

DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7; UniProt Q07864; also known as DNA polymerase II subunit A) is encoded by the POLE (also known as CRCS12, FILS, POLE1) gene (Gene ID 5426) in human. DNA polymerase II is one of the six known mamm

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DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7; UniProt Q07864; also known as DNA polymerase II subunit A) is encoded by the POLE (also known as CRCS12, FILS, POLE1) gene (Gene ID 5426) in human. DNA polymerase II is one of the six known mammalian template-directed DNA polymerases. It is composed of two subunits (261 kDa and 59 kDa). The larger catalytic subunit is a B-type polymerase family member, containing polymerase and intrinsic 3'-5' exonuclease activities in its N-terminal part and a putative zinc-finger domain in its C-terminus. POLE gene mutations are linked to colorectal cancer, facial dysmorphism, immunodeficiency, livedo, and short stature.
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