Anti-Mesothelin Antibody, clone MN-1 clone MN-1, from mouse

Mesothelin (UniProt: Q13421; also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, MSLN) is encoded by the MSLN (also known as MPF) gene (Gene ID: 10232) in human. Mesothelin is a glycophosphatidylinositol (GPI)-linked cell surface protein that normally expressed in lung and at lower levels in heart, placenta, and kidney. It is highly expressed in several types of malignant tumors and is associated with increased tumor aggressiveness and poor clinical outcome. Antibodies against mesothelin have been detected in patients with mesothelioma and ovarian cancer. Mesothelin plays a role in cellular adhesion. Mesothelin is synthesized with a signal peptide (aa 1-36) and a propeptide (aa 607-630) that are cleaved to produce mature mesothelin, which can be cleaved further by furin-like convertase to generate megakaryocyte-potentiating factor (aa 37-206) and the cleaved form of mesothelin (aa 296-606). Four isoforms of mesothelin have been described that are produced by alternative splicing. (Ref.: Inaguma, S., et al. (2017). Oncotarget. 8(16); 26744-26754; Onda, M., et al. (2005). Clin. Cancer Res, 11(16); 5840-5846).