Total PLCg2 Cellular Kit, 10000 Tests

The Total PLCg2 kit is designed to monitor the expression level of cellular PLCg2 (Phospholipase C), and can be used as a normalization assay for the Phospho-PLCg2 (Tyr1217) kit..This HTRF cell-based assay conveniently and accurately detects Phospholipase C gamma 2 (PLCgamma 2) protein. PLCgamma 2 is a phosphoinositide-specific phospholipase that generates second messengers and plays a crucial role in signal transduction, especially in haematopoietic cells such as B cells, mast cells, macrophages, natural killer cells and platelets. Upon stimulation of different receptors such as B-cell antigen receptor (BCR) and Fc receptors (FcRs), PLCgamma 2 interacts with several adapter proteins and becomes phosphorylated by intracellular tyrosine kinases. Phosphorylation includes several sites, one of which is Tyr1217. PLCgamma 2 has been linked to various pathologies such as auto-immune and inflammatory diseases, drug-resistance in cancer and neurodegeneration..