Anti-Neuregulin-2 Antibody (NRG2), clone 8D11 clone 8D11, from mouse

Pro-neuregulin-2, membrane-bound isoform (UniProt P56974; also known as Pro-NRG2) is encoded by the Nrg2 gene (Gene ID 100042150) in murine species. The ErbB4 receptor is widely expressed in GABAergic interneurons and reply on the engagement of neuregulins (NRGs) as ligands for signaling during neural processes in the adolescent and adult central nervous system (CNS). NRG1 transcript is generally lower than NRG2 in postnatal CNS and NRG2 is a major functional ErbB4 ligand in the postnatal brain. NRGs are synthesized as single-pass transmembrane pro-forms that is posttranslationally converted to signalling ligands by extracellular sheddases. The presence of an extracellular immunoglobulin (Ig)-like domain allows NRG1/2 ectodomain to accumulate near the site of cleavage through interactions with extracellular matrix heparan proteoglycans. NMDARs are required to release the NRG2 ectodomain from the surface of interneuron cell bodies. Stimulation of ErbB4 by the NRG2 ectodomain not only promotes the internalization of ion channels from the cell surface, but also the association of ErbB4 with GluN2B-containing NMDARs, resulting in a rapid downregulation of NMDARs on inhibitory interneurons, but not pyramidal neurons.