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IL-4Ralpha human recombinant, expressed in HEK 293 cells, >=98% (SDS-PAGE)

ITEM#: 3042-SRP619610UG

MFR#: SRP6196-10UG

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gammac). The type I receptor contains in addition to the gammac an IL-4Ralpha subunit, where as the type II receptor contains the IL-13Ralpha. The secret

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (gammac). The type I receptor contains in addition to the gammac an IL-4Ralpha subunit, where as the type II receptor contains the IL-13Ralpha. The secreted extracellular domain of IL-4Ralpha, called sIL-4Ralpha, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Ralpha is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-4Ralpha.