Anti-Amyloid beta Antibody, clone W0-2 clone WO2, from mouse

The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Abeta). Abeta is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Abeta [1-40], Abeta [1-42], and Abeta [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Abeta [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. These Amyloid beta antibodies and peptides have been developed as tools for elucidating the biology of AD.