Blood dendritic cell antigen 2 (BDCA-2;CD303) is a type II C-type lectin that is expressed on plasmacytoid dendritic cells (PDC), a subset of immature dendritic cells found in lymphoid and nonlymphoid tissues. BDCA-2 is critically involved in both ad
Blood dendritic cell antigen 2 (BDCA-2;CD303) is a type II C-type lectin that is expressed on plasmacytoid dendritic cells (PDC), a subset of immature dendritic cells found in lymphoid and nonlymphoid tissues. BDCA-2 is critically involved in both adaptive and innate immune responses. It is involved in the recognition and internalization of pathogens, but inhibits TLR6 signaling and INF-1 production, in PDC cells, possibly through signaling of the BCR-like signalosome. PDC signaling has been linked to multiple inflammatory diseases such as granulomatous lymphadenitis.
MRP8/ABCC11 is an interesting protein important in a wide range of cellular processes from bile acid metabolism to ear wax secretion. MRP8/ABCC11 is involved in the ATP-dependent uptake of lipophilic anions, steroid sulfates and various bile acids an
N-formy peptide receptor 1 (also known as N-formylpeptide chemoattractant receptor or fMet-Leu-Phe receptor) & 2 (also known as RFP, FMLP-R-I, Lipoxin A4 receptor, LXA4 receptor, FMLP-related receptor I, Formyl peptide receptor-like 1) are multi-pass
Myomesin-2 (UniProt: P54296; also known as 165 kDa connectin-associated protein, 165 kDa titin-associated protein, M-protein, Myomesin family member 2) is encoded by the MYOM2 gene (Gene ID: 9172) in human. Myomesin-2 is a major component of the vert
Nuclear receptor coactivator 2 (UniProt Q15596; also known as bHLHe75, Class E basic helix-loop-helix protein 75, hTIF2, NCoA-2, Transcriptional intermediary factor 2) is encoded by the NCOA2 (also known as BHLHE75, SRC2, TIF2) gene (Gene ID 10499) i
Peripherin-2 (UniProt: P17810; also known as Retinal degeneration slow protein) is encoded by the PRPH2 (also known as RDS) gene in bovine species. Peripherin-2 is a disulfide-linked homodimeric, multi-pass membrane protein that may function as an ad
Sulf-2 is also important in neurological situations including myelination and glial cell differentiation and GDNF activity. Sulf-2 activity is also found in the kidney and important in glomerular basement membrane development and glomerular function.
E3 ubiquitin-protein ligase MSL2 (UniProt Q9HCI7; also known as Male-specific lethal-2 homolog, Male-specific lethal-2 homolog 1, Male-specific lethal 2-like 1, MSL-2, MSL2-like 1, RING finger protein 184) is encoded by the MSL2 (also known as KIAA15
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (UniProt: Q9NYJ8; also known as Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2) is encoded