T-cell surface glycoprotein CD1b (UniProt: P29016; also known as CD1b) is encoded by the CD1B gene (Gene ID: 910) in human. CD1b is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell r
T-cell surface glycoprotein CD1b (UniProt: P29016; also known as CD1b) is encoded by the CD1B gene (Gene ID: 910) in human. CD1b is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. The most prominent known function of CD1b molecules is to associate with lipids from pathogens in order to stimulate T cells and induce host defense mechanisms. CD1b is expressed on cortical thymocytes, certain T-cell leukemia, and other tissues. Two isoforms of CD1b are reported that are produced by alternative splicing. CD1b has an extracellular domain (aa 18-3-3), a helical domain (aa 304-324), and a cytoplasmic tail (aa 329-332). The newly synthesized CD1b molecules follow an intracellular transport pathway that leads it to the cell surface from endoplasmic reticulum and subsequently to internalization from the plasma membrane into the endocytic pathway. After internalization, CD1b molecules are sorted for transport to lysosomes in the sorting endosome. (Ref.: Briken, V., et al. (2002). EMBO J. 21(4); 825-834).
T-cell surface glycoprotein CD1b (UniProt: P29016; also known as CD1b) is encoded by the CD1B gene (Gene ID: 910) in human. CD1b is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell r
The mouse monoclonal antibody SN13 (also known as K5-1B8) recognizes CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells.
Platelet glycoprotein 4 (UniProt: Q08857; also known as Glycoprotein IIIb, GPIIIB, PAS IV, PAS-4, Platelet glycoprotein IV, GPIV, CD antigen: CD36) is encoded by the cd36 gene (Gene ID: 12491) in murine species. CD36 is a multifunctional glycoprotein
Polyglutamine-binding protein 1 (UniProt: O60828; also known as PQBP-1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1) is encoded by the PQBP1 (also known as NPW38) gene (Gene ID: 10084) in human. PQBP-1
Transcription factor SOX-9 (UniProt P48436; also known as Sex-determining region Y-box 9 protein, SRY-related HMG-box gene 9) is encoded by the SOX9 (also known as CMD1, CMPD1, SRA1) gene (Gene ID 6662) in human. Sox family of genes are related to th
Obscurin, also known as Obscurin-RhoGEF or Obscurin-myosin light chain kinase, is encoded by the gene name OBSCN. Obscurin is involved in myofibrillogenesis and the assembly of myosin into sarcomeric A bands in striated muscle. Obscurin isoform 3 plu
Sortilin (UniProt Q99523; also known as 100 kDa NT receptor, Glycoprotein 95, Gp95, Neurotensin receptor 3, NT3, NTR3) is encoded by the SORT1 (also known as LDLCQ6, NT3) gene (Gene ID 6272) in human. Sortlin belongs to the family of sorting receptor
Lyso bis-phosphatidic acid (LBPA, Lysobisphosphatidic acid, L(bis)PA) is a lipid that is exclusively located in late endosomes and is used as a late endosome marker. One of the characteristic features of late endosomes is a complex system of internal
Serologically defined colon cancer antigen 8 (UniProt: Q86SQ7; also known as Antigen NY-CO-8, Centrosomal colon cancer autoantigen protein, hCCCAP, SDCCAG8) is encoded by the SDCCAG8 (also known as CCCAP, NPHP10) gene (Gene ID: 10806) in human. Serol