Anti-CD1d Antibody, clone WTH-1 clone WTH-1, from mouse

Antigen-presenting glycoprotein CD1d (UniProt Q63493; also known as CD1D antigen, CD1d1 antigen, T-cell surface glycoprotein CD1d) is encoded by the Cd1d (also known as Cd1d1) gene (Gene ID 25109) in rat species. CD1d is a nonpolymorphic MHC class I-like molecule which presents nonpeptide ligands (e.g. glycolipids) to natrual killer T (NKT) cells. NKT cells are known to have multiple effects on innate and adaptive immune responses and on the development of pathological conditions. In additon to hematopoietic cells, CD1d protein is also reported to be detected in non-lymphatic tissues in rat, such as the exocrine pancreas and Paneth cells. CD1d is initially produced with a signal peptide sequence (a.a. 1-17), the removal of which yields the mature CD1d with a large extracellular region (a.a.18-304), a transmembrane domain (a.a. 305-325), and a short cytoplasmic tail (a.a. 326-336).