Anti-Connexin 45 Antibody, clone P3C9 clone P3C9, from mouse

Gap junction gamma-1 protein (UniProt: A4GG66; also known as Connexin-45, Cx45, Gap junction alpha-7 protein) is encoded by the Gjc1 (also known as Gja7) gene (Gene ID: 266706) in rat. The gap junction channels are dodecamers of transmembrane proteins of the connexin family. Connexins usually have a short half-life ( 1.5 - 5 h) and this short half-life is a key element of coupling regulation as it allows very dynamic and acute changes in gap junction regulation and gap junctional communication. In cardiomyocytes three types of connexins have been identified: Connexin 40, 43, and 45. Each of these connexins form channels with unique and specific electrophysiological properties. Connexin-45 is a multi-pass membrane protein with ubiquitous expression. It consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low molecular weights diffuse from one cell to a neighboring cell. Connexin 45 is the first cardiac connexin expressed during embryonic development and plays an important role in propagating the action potential from the conduction system to the working myocardium. Connexin 45 gap junction channels are reported to close when the membrane potential becomes negative. This prevents retrograde conduction from myocardium to the conduction system.