Monoclonal Anti-p53 (mouse Ig2a isotype) is derived from the BP53-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with recombinant human wild-type p53 protein. The tumor suppressor gene TP53 (gene
The p53 protein was first identified in a complex with the simian virus 40 (SV40) large T-antigen.4-5 p53 is classified as a key tumor suppressor and is the most commonly mutated gene in human cancers; it is mutated in over 50% of all human cancers.6