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Anti-Vasohibin-1 Antibody, clone 4E12 (Azide Free) clone 4E12, 1 mg/mL, from mouse

ITEM#: 3042-MABC537

MFR#: MABC537

Vasohibin-1 is an endothelium-derived negative feedback regulator of angiogenesis. Vasohibin-1 inhibited migration, proliferation, and network formation by ECs in culture, as well as angiogenesis in vivo, and Vasohibin-1 was selective for endothelial

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Vasohibin-1 is an endothelium-derived negative feedback regulator of angiogenesis. Vasohibin-1 inhibited migration, proliferation, and network formation by ECs in culture, as well as angiogenesis in vivo, and Vasohibin-1 was selective for endothelial cells and its influence was eliminated by hypoxia or TNF-alpha interaction. Vasohibin is preferentially expressed in endothelial cells and does not appear to promote proliferation or tumor growth when over expressed. Vasohibin-1 expression is induced by VEGF expression and its effects are mediated through VEGF-R2 independent of VEGF-R1 and Vasohibin-1 may directly influence the expression of VEGF-R2. Because the inhibition effects of Vasohibin-1 are nullified by hypoxia and various cytokines it is thought that this is how tumors escape this built-in negative regulator of angiogenesis. Vasohibin-1 is highly expressed in fetal organs and the endothelial cells during development, and also expressed in the brain and placental and microvessels endothelial cells of atherosclerotic lesions in the adult.
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Product Name Description Item# QTY
Anti-Dab1 Antibody, clone 4E12 clone 4E12, from rat Disabled homolog 1 (UniProt: P97318; also known as DAB1) is encoded by the Dab1 gene (Gene ID: 13131) in murine species. Dab 1 is mainly expressed in the brain and serves as an adapter molecule involved in neural development where it is reported to d 3042-MABN227625UL EA
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