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BioTracker Green HOCl-CM2 Live Cell Dye

ITEM#: 3042-SCT078

MFR#: SCT078

Alzheimer's disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. AD is associated with generation of excessive reactive oxygen species (ROS) in the brain, which c

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Alzheimer's disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. AD is associated with generation of excessive reactive oxygen species (ROS) in the brain, which cause oxidative stress and inflammation. ROS production involves elevated levels of hypochlorous acid (HOCl) and can serve as a potential biomarker of AD pathogenesis along with amyloid plagues.BioTracker Green HOCl-CM2 Live Cell Dye is a switchable coumarin-morpholine (CM) off-on fluorescence probe for the specific detection of HOCl produced and proximally localized with amyloid plaques. The nonfluorescent thioamide probe undergoes regioselective transformation to fluorescent amide probe in the presence of HOCl with high selectivity and sensitivity. This probe has excellent cellular uptake and can penetrate the blood-brain barrier (BBB) enabling detection, imaging, and quantification of HOCl in vitro and in vivo.Spectral PropertiesAbsorbance: 417 nmEmission: 485 nmReference:1. Samanta, S., & Govindaraju, T. (2019). Unambiguous detection of elevated levels of hypochlorous acid in double transgenic AD mouse brain. ACS chemical neuroscience, 10(12), 4847-4853.
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Product Name Description Item# QTY
BioTracker TP-HOCL1 Live Cell Dye Live cell imaging dye for hypochlorus acid (HOCL) used to detect phagocytosis, inflammation and cellular apoptosis. Hypochlorous acid (HOCl) is a highly potent reactive oxygen species (ROS) and helps eliminate pathogens in the innate immune system. Mounting evidence indicates that intracellular HOCl plays additional important roles in regulating inflammation and c 3042-SCT043 EA
BioTracker CoxFluor Live Cell Dye Cyclooxygenase (COX), also known as Prostaglandin-endoperoxide synthase (PTGS), is the key enzyme in prostaglandin biosynthesis. There are two isozymes of cyclooxygenase: a constitutive COX-1 and an inducible COX-2, which differ in their regulation o 3042-SCT079 EA
BioTracker 574 Red HOCL Dye Live cell imaging dye for hypochlorous acid (HOCl) used to detect phagocytosis, inflammation and cellular apoptosis. The production of hypochlorous acid (HOCl) by the myeloperoxidase-H2O2-Cl- system of phagocytes plays a vital role in the ability of immune cells to kill a wide range of pathogens including bacteria and viruses. Hypochlorous acid is one of the variou 3042-SCT034 EA
BioTracker Rd1 Hypochlorite Live Cell Dye Antibody, Green Hypochlorite (HClO/ClO-) is a reactive oxygen species (ROS) produced by the enzyme myeloperoxidase (MPO), which catalyzes the reaction of hydrogen peroxide (H2O2) and chloride ion (Cl-), and plays an important role in the immune response to defend ag 3042-SCT080 EA
BioTracker Green Sulfane Sulfur live cell dye BioTracker Green Sulfane Sulfur live cell dye Live Cell imaging probe for sulfane sulfur species including persulfide (R-S-SH), polysulfide (R-S-S<sub>n</sub>-S-R) and ploysulfide (H<sub>2</sub>S<sub>n</sub>). Intracellularly abundant sulfane sulfur 3042-SCT211 EA
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