Phospho-PLCg2 (Tyr1217) Cellular Kit, 500 Tests

This HTRF kit enables the cell-based quantitative detection of phosphorylated PLCg2 (Phospholipase C gamma 2) at Tyr1217, as a readout of multiple adaptive and innate immune cell surface receptors.This HTRF cell-based assay conveniently and accurately detects phosphorylated Phospholipase C gamma 2 (PLCgamma 2) at Tyr1217. PLCgamma 2 is a phosphoinositide-specific phospholipase that generates second messengers and plays a crucial role in signal transduction, especially in haematopoietic cells such as B cells, mast cells, macrophages, natural killer cells and platelets. Upon stimulation of different receptors such as B-cell antigen receptor (BCR) and Fc receptors (FcRs), PLCgamma 2 interacts with several adapter proteins and becomes phosphorylated by intracellular tyrosine kinases. Phosphorylation includes several sites, one of which is Tyr1217. PLCgamma 2 has been linked to various pathologies such as auto-immune and inflammatory diseases, drug-resistance in cancer and neurodegeneration.