Ubiquitin-Eu cryptate, 5000 Tests

Ubiquitin labeled with Europium Cryptate to monitor protein ubiquitination.Ubiquitination plays a key role in regulating protein degradation, and is carried out by the conjugation of ubiquitin to target proteins through the sequential activity of three enzymes: E1, E2 and E3. Poly-ubiquitinated proteins are then subject to degradation by proteasomes. The ubiquitin pathway is associated with many pathologies such as cancer, muscle atrophy, inflammation, viral infection, and metabolic and neurodegenerative disorders. The Ubiquitin-Eu cryptate allows flexible assay development assessing each step in the ubiquitin pathway..